1. Is the fault in the components that perform any physical action?
Answer: No
2. Is the faulty component part of the mechanism’s body?
Answer: No
3. Is the faulty component in the fuel system?
Answer: Yes
4. Is the fault in the fuel filtration system?
Answer: Yes
5. Is the fault in the fuel filtration components?
Answer: Yes
6. Is the fault in the components responsible for removing fuel consumption by products?
Answer: No
7. Is removal of the damaged section possible?
Answer: No
8. Can other parts of the mechanism be used to minimize the effect of the fault?
Answer: Yes
9. Is there a trigger event to begin the replacement of the component?
Answer: No
10. Are there any external resources that can be used by the damaged component?
Answer: No
81) Whitespotted Bamboo Shark, Chiloscyllium plagiosum
Whitespotted Bamboo Sharks can be found in the west Pacific Ocean (Kune & Burgess). The Whitespotted Bamboo Shark is capable of regenerating its liver after some sort of injury.
After the liver has undergone damage there are three target miRNAs that are signaled which are: hsa-miR-142-3p_R-1, xtr-miR-125b, and fru-miR-204 (Conger et al..). These three target miRNAs have been found to be generated more during the early and late times of regeneration which corresponds to apoptotic activity (Conger et al.). While these miRNAs are overexpressed the liver cannot undergo liver regeneration, but once they go back to normal levels hepatic stem cells are able to proliferate. These cells will proliferate and join together to form the missing parts of the liver. Once the liver has reached its maximum size and are not needed anymore miRNAs are generated as a negative feedback mechanism to stop cell proliferation (Conger et al.).
Kyne, P.M. & Burgess, G.H. 2006. Chiloscyllium plagiosum. The IUCN Red List of Threatened Species. Version 2014.3. Web. 17 Dec. 2014.
http://www.iucnredlist.org/details/60222/0
Conger Lu, Jie Zhang, Zuoming Nie, et al., ÒStudy of MicroRNAs Related to the Liver Regeneration of the Whitespotted Bamboo Shark, Chiloscyllium plagiosum,Ó BioMed Research International, vol. 2013, Article ID 795676, 12 pages, 2013. Web 17 Dec. 2014.
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