Path followed:
- Is the fault in the components that perform any physical action?
Answer: No
- Is the faulty component part of the mechanism’s body?
Answer: Yes
- Is the faulty component in the structure of the mechanism?
Answer: Yes
- Does the fault appear in components that provide rigidity to the mechanism?
Answer: Yes
- Can the faulty component be removed from the mechanism?
Answer: No
- Is the fault in load bearing components?
Answer: Yes
58) Human, Homo sapiens
Humans have the ability of healing a broken bone through a regenerative process. After the bone is broken undifferentiated mesenchymal cells will migrate to the injured site by signals such as beta-catenin and canonical signaling (Chen et al.). Once at the injured site the cells will proliferate and start differentiating into specialized cells. Intramembranous ossification uses the mesenchymal cells and osteoprogenitor cells to create a hard callus formation which will in turn will create the bone (Chen et al.). Endochondral ossification is also taking place which uses mesenchymal cells that differentiate into chrondrocytes. Chrondrocytes produce a cartilaginous matrix which will later calcify and is replaced by bone (Chen et al.). The cells will continue to proliferate and turn into calciferous material until the bone has regained its original size and shape. After the bone has healed the cells will stop proliferating and disperse away from the previously injured site.
Chen, Yan, Heather C. Whetstone, Alvin C. Lin, Puviindran Nadesan, Qingxia Wei, Raymond Poon, and Benjamin A. Alman. “Beta-Catenin Signaling Plays a Disparate Role in Different Phases of Fracture Repair: Implications for Therapy to Improve Bone Healing.” PLoSONE 4.7 (2007): E249. NCBI. Web. 7 Dec. 2014.
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