1. Is the fault in the components that perform any physical action?
Answer: No
2. Is the faulty component part of the mechanism’s body?
Answer: Yes
3. Is the faulty component in the structure of the mechanism?
Answer: Yes
4. Does the fault appear in components that provide rigidity to the mechanism?
Answer: No
5. Is the faulty component responsible for supporting other components?
Answer: No
6. Does the faulty component provide filtration?
Answer: Yes
46) Human, Homo sapiens
Glomerulosclerosis occurs when the podocytes that surround the glomerulus in the kidney are depleted (NIH). The podocytes help the kidney filter the toxins out of the body and keep the protein and other things the body can use in the body (Pavenstadt et al.). In order for the body to filter out the toxins and heal the kidneys the podocytes must be regenerated and researches have found cells in the body that have the potential to do that. There are progenitor cells in the BowmanÕs capsule called CD133+CD24+ that can proliferate and differentiate into the
podocytes (Pavenstadt et al.). The more progenitor cells that are produced the more podocytes can be produced and help the kidney return to its proper filtering state.
NIH. “Glomerular Diseases.” Glomerular Diseases- National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC). NIH Publication, Feb. 2014. Web. 7 Dec. 2014.
http://kidney.niddk.nih.gov/KUDiseases/pubs/glomerular/index.aspx
Pavenstadt, Hermann, Wilhelm Kriz, and Matthias Kretzler. “Cell Biology of the Glomerular Podocyte.” Physiological Reviews 83.1 (2003): 253-307. Physiological Reviews. Web. 9 Dec. 2014.
Recent Comments