Replace 29

Path followed:

1.   Is the fault in the components that perform any physical action?

Answer: No

2.   Is the faulty component part of the mechanism’s body?

Answer: No

3.   Is the faulty component in the fuel system?

Answer: Yes

4.   Is the fault in the fuel filtration system?

Answer: Yes

5.   Is the fault in the fuel filtration components?

Answer: Yes

6.   Is the fault in the components responsible for removing fuel consumption by products?

Answer: No

7.   Is removal of the damaged section possible?

Answer: No

8.   Can other parts of the mechanism be used to minimize the effect of the fault?

Answer: Yes

9.   Is there a trigger event to begin the replacement of the component?

Answer: No

10. Are there any external resources that can be used by the damaged component?

Answer: Yes

 

29) Rat, Rattus

Rats can be found all over the world and can live for up to 5 years (ÒRatÓ). Rats have the ability of regenerating their liver after partial hepatectomy.

Partial hepatectomy is the surgical removal of the damaged part of the liver. In order for the liver to gain back the mass of tissue that was lost it uses already existing hepatocytes to undergo replication (Michalopoulos). The hepatocytes undergo replication in synch with the circadian rhythm of the animal, which is 24 hours after the operation on the ratÕs liver (Michalopoulos). There are many signals from the cytokine network that are induced in order for the hepatocytes to replicate and regrow the liver. HGF and EGF receptor ligand family have been found to be important growth factors in initiating and controlling the cell cycle of the hepatocytes (Michalopoulos). The hepatocytes will continue to
replicate until the liver has reached its maximum size again and then the cells will go into quiescent stage of the cycle.

“Rat.” Rat (tus Tus). Http://a-z-animals.com/, 2013. Web. 1 Dec. 2014.

http://a-z-animals.com/animals/rat/

Michalopoulos, George K. “Liver Regeneration after Partial Hepatectomy.” The American Journal of Pathology 176.1 (2010): 2-13. NCBI. Web. 1 Dec. 2014.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797862/