Replace 21

Path followed:

1.   Is the fault in the components that perform any physical action?

       Answer: No

2.   Is the faulty component part of the mechanism’s body?

Answer: No

3.   Is the faulty component in the fuel system?

Answer: Yes

4.   Is the fault in the fuel filtration system?

Answer: Yes

5.   Is the fault in the fuel filtration components?

Answer: Yes

6.   Is the fault in the components responsible for removing fuel consumption by products?

Answer: No

7.   Is removal of the damaged section possible?

Answer: Yes

 

21) Human, Homo sapiens

Over the years humans have become more technologically advanced. This has helped to create things and heal animals, which could not have been possible 50 years ago. Scientists have found that humans are also capable of regenerating a major portion of their liver if it was damaged.

Once there has been damage to the liver able hepatocytes will start to proliferate near the site damaged site. Various signals are required to initiate and control the proliferating and differentiating process, such as c-Jun, signal transducer and activator of transcription 3, CAAT enhancer-binding protein beta, and cAMP-responsive element modulator (Out et al.). Macrophages will also migrate toward the necrotic site and clear the liver of the dead cells so the new cells that are being produced can work properly (Hoehme et al.). Once all of the dead cells are removed the macrophages will disperse to other parts of the body. mRNA also increases in production so the cells are able to differentiate into the different parts of the liver (Hoehme et al.). Once the liver has recovered its density and is able to perform properly hepatocyte replication will cease.

Otu, Hasan H., Kamila Naxerova, Karen Ho, Handan Can, Nicole Nesbitt, Towia A. Libermann, and Seth J. Karp. “Restoration of Liver Mass after Injury Requires Proliferative and Not Embryonic Transcriptional Patterns.”The Journal of Biological Chemistry 282 (2007): 11197-1204. The Journal of Biological Chemistry. Web. 25 Nov. 2014.

http://www.jbc.org/content/282/15/11197.full

Hoehme, Stefan, Marc Brulport, Alexander Bauer, Essam Bedawy, Wiebke Schormann, Matthias Hermes, Verena Puppe, Rolf Gebhardt, Sebastian Zellmer, Michael Schwarz, Ernesto Bockamp, Tobias Timmel, Jan G. Hengstler, and Dirk Drasdo. “Prediction and Validation of Cell Alignment along Microvessels as Order Principle to Restore Tissue Architecture in Liver Regeneration.” PNAS107.23 (2010): 10371-0376. Proceedings of the National Academy of Sciences of the United States of America. Web. 25 Nov. 2014.

http://www.pnas.org/content/107/23/10371.full